Endocrine Abstracts

Background: Obesity is often complicated by cardiovascular and atherosclerotic disease. Central or visceral obesity is known to be associated with hypertension and cardiovascular disease. Even though BMI is a good indicator of obesity in epidemiological studies, it does not differentiate between lean and fat mass. Furthermore waist circumference (WC) and visceral fat percentages are better indicators of visceral obesity. Aim of this study was to investigate the correlation of ...

Background: Androgens promote erythropoiesis and have been used for the treatment of anaemia. Furthermore, polycythemia is a known side effect of androgen therapy. In congenital adrenal hyperplasia (CAH), elevated adrenal androgens cause virilisation of female patients. Glucocorticoid treatment reduces androgen levels but there is a difficult balance between excess androgens and suppressed androgens due to excess glucocorticoid treatment.Aim of study: To...

Introduction: Graves thyrotoxicosis can be life-threatening if uncontrolled. Resistant thyrotoxicosis is not uncommon and may require urgent intervention. We present a case with severe refractory thyrotoxicosis which required urgent total thyroidectomy following bridging plasma exchange.Case History: A 35-year-old male with Grave’s disease presented with persistent thyrotoxic symptoms despite medical management for 10 months. Clinically he was hyper...

Introduction: Visceral adiposity is shown to be associated with cardiovascular disease. Aim of this study was to evaluate the usefulness of visceral fat percentage (VF%) and body fat percentage (BF%), compared to anthropometric parameters, BMI waist circumference (WC), and waist – hip ratio(WHR) in predicting obesity and cardiovascular risk.Method: A descriptive cross sectional study conducted within five health divisions in Colombo district in Sri ...

Background: In men there is a strong relationship between androgens and erythropoiesis; however this has not been shown in women. Patients with congenital adrenal hyperplasia (CAH) if uncontrolled may have high androgen levels and if over treated with glucocorticoids low androgen levels. Therefore CAH provides a potential model to examine the relationship between androgens and erythropoiesis in women.Aim: To investigate the relationship between androgens...

Introduction: Obesity is associated with increased prevalence of cardiovascular(CV) risk factors and mortality and the CV risk factors are known to reduce following bariatric surgery. The aim of this analysis was to determine the effect of bariatric surgery on CV risk factors and CV risk score.Method: A prospective analytical study of the first 15 consecutive patients who underwent laparoscopic Sleeve Gastrectomy procedure from 2009 to 2011 in Colombo. B...

Background: Congenital adrenal hyperplasia (CAH) is a rare condition that is associated with life long risk of adrenal crisis. Management of CAH demands a fine balance between excess glucocorticoid leading to adverse effects and too little glucocorticoid risking adrenal crises. Frequent occurrence of sick day episodes warrants dose adjustment and education regarding adrenal crisis. In a condition such as CAH it is difficult to collect sufficient data from small cohorts at a si...